Murielle Telio was born in New York City, New York, to parents, Janine , a clothing wholesaler, and Ike Telio, a financial analyst. She is of French, Italian, Spanish, and Lebanese ancestry. Murielle was raised in New Orleans, Louisiana. She attended Tulane University, after two years, majoring in English and Theater, she decided to move on Los Angeles and concentrate more on acting. She is a poet, a novelist, and has written multiple screenplays. As an actress, she played "Ashley" on the "HBO" series, East Bound and Down, and a Pin Up Porn Star Muse "Misty Mountains" that conspired to take on the corrupt Detroit automobile industry in Shane Black's, The Nice Guys. She has also appeared on Marvel's Agents of Shield and recurred on David Gordon Green and Steve Soderbergh's series, Red Oaks. She has also appeared in The Duff, and Game of Assassins.
